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Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase

Orotidine 5′-monophosphate decarboxylase catalyzes the conversion of orotidine 5′-monophosphate to uridine 5′-monophosphate, the last step in biosynthesis of pyrimidine nucleotides. As part of a Structural Genomics Initiative, the crystal structures of the ligand-free and the6-azauridine 5′-monophos...

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Main Authors: Wu, Ning, Mo, Yirong, Gao, Jiali, Pai, Emil F.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC15746/
https://ncbi.nlm.nih.gov/pubmed/10681441
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