Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase
Orotidine 5′-monophosphate decarboxylase catalyzes the conversion of orotidine 5′-monophosphate to uridine 5′-monophosphate, the last step in biosynthesis of pyrimidine nucleotides. As part of a Structural Genomics Initiative, the crystal structures of the ligand-free and the6-azauridine 5′-monophos...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2000
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15746/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681441/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.050417797 |
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