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Molecular dynamic study of orotidine-5′-monophosphate decarboxylase in ground state and in intermediate state: A role of the 203–218 loop dynamics

Molecular dynamics simulations have been used to derive the structures of ground (orotidine-5′-monophosphate decarboxylase⋅orotidine 5′-monophosphate; ODC⋅OMP) and intermediate (ODC⋅intermediate; ODC⋅I(−)) states in the ODC-catalyzed decarboxylation of OMP. For comparison, a molecular dynamics simul...

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Detalhes bibliográficos
Main Authors: Hur, Sun, Bruice, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC124970/
https://ncbi.nlm.nih.gov/pubmed/12107279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.142307099
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