Anatomy of a proficient enzyme: The structure of orotidine 5′-monophosphate decarboxylase in the presence and absence of a potential transition state analog

Orotidine 5′-phosphate decarboxylase produces the largest rate enhancement that has been reported for any enzyme. The crystal structure of the recombinant Saccharomyces cerevisiae enzyme has been determined in the absence and presence of the proposed transition state analog 6-hydroxyuridine 5′-phosp...

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Bibliografiska uppgifter
Huvudupphovsmän: Miller, Brian G., Hassell, Anne M., Wolfenden, Richard, Milburn, Michael V., Short, Steven A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2000
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC15745/
https://ncbi.nlm.nih.gov/pubmed/10681417
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