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G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal

1. Tolerance to opioids frequently follows repeated drug administration and affects the clinical utility of these analgesics. Studies in simple cellular systems have demonstrated that prolonged activation of opioid receptors produces homologous receptor desensitization by G-protein receptor kinase m...

詳細記述

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書誌詳細
主要な著者: Terman, Gregory W, Jin, Wenzhen, Cheong, Young-Pyo, Lowe, Janet, Caron, Marc G, Lefkowitz, Robert J, Chavkin, Charles
フォーマット: Artigo
言語:Inglês
出版事項: 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574178/
https://ncbi.nlm.nih.gov/pubmed/14662727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705595
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