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Mu Opioid Receptor Activation of ERK1/2 Is GRK3 and Arrestin Dependent in Striatal Neurons

In this study we investigated the mechanisms responsible for MAP kinase ERK1/2 activation following agonist activation of endogenous mu opioid receptors (MOR) normally expressed in cultured striatal neurons. Treatment with the MOR agonist fentanyl caused significant activation of ERK1/2 in neurons d...

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Detalhes bibliográficos
Main Authors: Macey, Tara A., Lowe, Janet D., Chavkin, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2104781/
https://ncbi.nlm.nih.gov/pubmed/16982618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M604278200
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