Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

There is ongoing debate about the role of G protein–coupled receptor kinases (GRKs) in agonist-induced desensitization of the μ-opioid receptor (MOPr) in brain neurons. In the present paper, we have used a novel membrane-permeable, small-molecule inhibitor of GRK2 and GRK3, Takeda compound 101 (Cmpd...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Lowe, Janet D., Sanderson, Helen S., Cooke, Alexandra E., Ostovar, Mehrnoosh, Tsisanova, Elena, Withey, Sarah L., Chavkin, Charles, Husbands, Stephen M., Kelly, Eamonn, Henderson, Graeme, Bailey, Chris P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518089/
https://ncbi.nlm.nih.gov/pubmed/26013542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.098293
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