Effect of fentanyl on 5-HT efflux involves both opioid and 5-HT(1A) receptors

1. Fentanyl is a μ-opioid analgesic that might disinhibit 5-HT neurons and thus increase 5-HT efflux. However, fentanyl also binds to 5-HT(1A) receptors, and if it activates 5-HT(1A) somatodendritic autoreceptors, the resultant inhibition might offset opioid-mediated increases in 5-HT efflux. To tes...

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Bibliografiske detaljer
Main Authors: Tao, Rui, Karnik, Meghana, Ma, Zhiyuan, Auerbach, Sidney B
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573976/
https://ncbi.nlm.nih.gov/pubmed/12922937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705378
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