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Effect of fentanyl on 5-HT efflux involves both opioid and 5-HT(1A) receptors
1. Fentanyl is a μ-opioid analgesic that might disinhibit 5-HT neurons and thus increase 5-HT efflux. However, fentanyl also binds to 5-HT(1A) receptors, and if it activates 5-HT(1A) somatodendritic autoreceptors, the resultant inhibition might offset opioid-mediated increases in 5-HT efflux. To tes...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573976/ https://ncbi.nlm.nih.gov/pubmed/12922937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705378 |
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