Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics

1. Ethanol and nicotine are commonly coabused drugs. Cytochrome P450 2E1 (CYP2E1) metabolizes ethanol and bioactivates tobacco-derived procarcinogens. Ethanol and nicotine can induce hepatic CYP2E1 and we hypothesized that both centrally active drugs could also induce CYP2E1 within the brain. 2. Mal...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Howard, Lisa A, Miksys, Sharon, Hoffmann, Ewa, Mash, Deborah, Tyndale, Rachel F
Format: Artigo
Jezik:Inglês
Izdano: 2003
Teme:
Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573767/
https://ncbi.nlm.nih.gov/pubmed/12711639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705146
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki