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Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics
1. Ethanol and nicotine are commonly coabused drugs. Cytochrome P450 2E1 (CYP2E1) metabolizes ethanol and bioactivates tobacco-derived procarcinogens. Ethanol and nicotine can induce hepatic CYP2E1 and we hypothesized that both centrally active drugs could also induce CYP2E1 within the brain. 2. Mal...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573767/ https://ncbi.nlm.nih.gov/pubmed/12711639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705146 |
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