Bertosamil blocks HERG potassium channels in their open and inactivated states

1. Bertosamil is chemically related to the class-III anti-arrhythmic drug tedisamil and has been developed as a bradycardic, anti-ischemic and anti-arrhythmic drug. Its anti-arrhythmic properties might in part be attributed to its block of voltage-dependent potassium channels Kv(1.2), Kv(1.4). and K...

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Hlavní autoři: Zitron, Edgar, Karle, Christoph A, Wendt-Nordahl, Gunnar, Kathöfer, Sven, Zhang, Wei, Thomas, Dierk, Weretka, Slawomir, Kiehn, Johann
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573484/
https://ncbi.nlm.nih.gov/pubmed/12208779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704859
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