Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

1. The inhibition of the cardiac ‘rapid' delayed rectifier current (I(Kr)) and its cloned equivalent HERG mediate QT interval prolonging effects of a wide range of clinically used drugs. In this study, we investigated the effects of the Class Ic antiarrhythmic agent flecainide (FLEC) on ionic c...

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Hlavní autoři: Paul, Ashok A, Witchel, Harry J, Hancox, Jules C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573407/
https://ncbi.nlm.nih.gov/pubmed/12086981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704784
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