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Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

1. The inhibition of the cardiac ‘rapid' delayed rectifier current (I(Kr)) and its cloned equivalent HERG mediate QT interval prolonging effects of a wide range of clinically used drugs. In this study, we investigated the effects of the Class Ic antiarrhythmic agent flecainide (FLEC) on ionic c...

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書誌詳細
主要な著者: Paul, Ashok A, Witchel, Harry J, Hancox, Jules C
フォーマット: Artigo
言語:Inglês
出版事項: 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573407/
https://ncbi.nlm.nih.gov/pubmed/12086981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704784
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