Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

1. Challenge of COS1 cells with the adenylyl cyclase activator forskolin led to the activation of recombinant PDE4A8, PDE4B1, PDE4C2 and PDE4D5 cAMP-specific phosphodiesterase long isoforms. 2. Forskolin challenge did not activate mutant long PDE4 isoforms where the serine target residue (STR) withi...

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Detalhes bibliográficos
Main Authors: MacKenzie, Simon J, Baillie, George S, McPhee, Ian, MacKenzie, Carolynn, Seamons, Rachael, McSorley, Theresa, Millen, Jenni, Beard, Matthew B, van Heeke, Gino, Houslay, Miles D
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573369/
https://ncbi.nlm.nih.gov/pubmed/12023945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704743
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