SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue

1. A novel compound, SB-272183 (5-Chloro-2, 3-dihydro-6-[4-methylpiperazin-1-yl]-1[4-pyridin-4-yl]napth-1-ylaminocarbonyl]-1H-indole), has been shown to have high affinity for human 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptors with pK(i) values of 8.0, 8.1 and 8.7 respectively and is at least 30 fold s...

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Detalhes bibliográficos
Main Authors: Watson, J, Roberts, C, Scott, C, Kendall, I, Collin, L, Day, N C, Harries, M H, Soffin, E, Davies, C H, Randall, A D, Heightman, T, Gaster, L, Wyman, P, Parker, C, Price, G W, Middlemiss, D N
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572841/
https://ncbi.nlm.nih.gov/pubmed/11454652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704133
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