SB-224289–a novel selective (human) 5-HT(1B) receptor antagonist with negative intrinsic activity

1. Human 5-HT(1B) (h5-HT(1B)) and human 5-HT(1D) (h5-HT(1D)) receptors show remarkably similar pharmacology with few compounds discriminating the receptors. We report here on a novel compound, SB-224289 (1′-Methyl-5-[[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrah...

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Detalhes bibliográficos
Main Authors: Selkirk, J V, Scott, C, Ho, M, Burton, M J, Watson, J, Gaster, L M, Collin, L, Jones, B J, Middlemiss, D N, Price, G W
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565605/
https://ncbi.nlm.nih.gov/pubmed/9776361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702059
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