Chronic systemic administration of salmeterol to rats promotes pulmonary β(2)-adrenoceptor desensitization and down-regulation of G(sα)

1. The aim of the present study was to examine the effects of chronic infusion of the long-acting agonist salmeterol on pulmonary β(2)-adrenoceptor function in Sprague-Dawley rats in vivo and to elucidate the molecular basis of any altered state. 2. Systemic administration of rats with salmeterol fo...

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Detalhes bibliográficos
Main Authors: Finney, Paul A, Donnelly, Louise E, Belvisi, Maria G, Chuang, Tsu-Tshen, Birrell, Mark, Harris, Andrew, Mak, Judith C W, Scorer, Carol, Barnes, Peter J, Adcock, Ian M, Giembycz, Mark A
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572675/
https://ncbi.nlm.nih.gov/pubmed/11250877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703946
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