Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase

1. The spasmolytic and anti-spasmogenic activity of β-adrenoceptor agonists on airways smooth muscle is thought to involve activation of the cyclic AMP/cyclic AMP-dependent protein kinase (PKA) cascade. Here we have tested the hypothesis that PKA mediates the anti-spasmogenic activity of isoprenalin...

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Detalhes bibliográficos
Main Authors: Spicuzza, Lucia, Belvisi, Maria G, Birrell, Mark A, Barnes, Peter J, Hele, David J, Giembycz, Mark A
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1621162/
https://ncbi.nlm.nih.gov/pubmed/11498504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704213
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