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Modelling of the blood-brain barrier transport of morphine-3-glucuronide studied using microdialysis in the rat: involvement of probenecid-sensitive transport
1. The objective of this study was to investigate the impact of probenecid on the blood-brain barrier (BBB) transport of morphine-3-glucuronide (M3G). 2. Two groups of rats received an exponential infusion of M3G over 4 h to reach a target plasma concentration of 65 μM on two consecutive days. Probe...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572517/ https://ncbi.nlm.nih.gov/pubmed/11139459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703759 |
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