The influence of age on the distribution of morphine and morphine-3-glucuronide across the blood–brain barrier in sheep

BACKGROUND AND PURPOSE: The effect of age on the distribution of morphine and morphine-3-glucuronide (M3G) across the blood–brain barrier (BBB) was studied in a sheep model utilizing intracerebral microdialysis. The effect of neonatal asphyxia on brain drug distribution was also studied. EXPERIMENTA...

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Главные авторы: Bengtsson, J, Ederoth, P, Ley, D, Hansson, S, Amer-Wåhlin, I, Hellström-Westas, L, Marsál, K, Nordström, C-H, Hammarlund-Udenaes, M
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2009
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737667/
https://ncbi.nlm.nih.gov/pubmed/19438510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00242.x
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