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Modelling of the blood-brain barrier transport of morphine-3-glucuronide studied using microdialysis in the rat: involvement of probenecid-sensitive transport

1. The objective of this study was to investigate the impact of probenecid on the blood-brain barrier (BBB) transport of morphine-3-glucuronide (M3G). 2. Two groups of rats received an exponential infusion of M3G over 4 h to reach a target plasma concentration of 65 μM on two consecutive days. Probe...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Xie, Rujia, Bouw, M René, Hammarlund-Udenaes, Margareta
פורמט: Artigo
שפה:Inglês
יצא לאור: 2000
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572517/
https://ncbi.nlm.nih.gov/pubmed/11139459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703759
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