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The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice
1. The aim of this study was to investigate whether blood-brain barrier transport of morphine was affected by the absence of mdr1a-encoded P-glycoprotein (Pgp), by comparing mdr1a (−/−) mice with mdr1a (+/+) mice. 2. Mdr1a (−/−) and (+/+) mice received a constant infusion of morphine for 1, 2 or 4 h...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571655/ https://ncbi.nlm.nih.gov/pubmed/10516633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702804 |
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