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A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188
1. (+)-ROD188 was synthesized in the search for novel ligands of the GABA binding site. It shares some structural similarity with bicuculline. (+)-ROD188 failed to displace [(3)H]-muscimol in binding studies and failed to induce channel opening in recombinant rat α1β2γ2 GABA(A) receptors functionall...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572371/ https://ncbi.nlm.nih.gov/pubmed/11030736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703558 |
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