Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β(2) subunit of GABA(A) receptors?

NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein coupled receptors GPR18 and GPR92. Recently, we have...

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Bibliographic Details
Main Authors: Baur, Roland, Gertsch, Jürg, Sigel, Erwin
Format: Artigo
Language:Inglês
Published: PeerJ Inc. 2013
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775635/
https://ncbi.nlm.nih.gov/pubmed/24058880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.149
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