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Dual mode of stimulation by the β-carboline ZK 91085 of recombinant GABA(A) receptor currents: molecular determinants affecting its action
1. In electrophysiological measurements the β-carboline ethyl 6-benzyloxy-β-carboline-3-carboxylate (ZK 91085) acts as a positive allosteric modulator on rat recombinant α1β2γ2 GABA(A) receptors and binds with high affinity (IC(50)=1.5 nM) to the [(3)H]-flunitrazepam site. Flumazenil was able to par...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
1999
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1566114/ https://ncbi.nlm.nih.gov/pubmed/10455270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702639 |
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