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Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner

1. Sphingolipids such as sphingosine-1-phosphate (SPP) and sphingosylphosphorylcholine constrict isolated rat intrarenal and mesenteric microvessels in vitro. The present study investigates their effects on the cardiovascular system in vivo in anaesthetized rats. 2. The animals were given intravenou...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bischoff, Angela, Czyborra, Peter, Meyer zu Heringdorf, Dagmar, Jakobs, Karl H, Michel, Martin C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572274/
https://ncbi.nlm.nih.gov/pubmed/10952678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703516
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