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Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner

1. Sphingolipids such as sphingosine-1-phosphate (SPP) and sphingosylphosphorylcholine constrict isolated rat intrarenal and mesenteric microvessels in vitro. The present study investigates their effects on the cardiovascular system in vivo in anaesthetized rats. 2. The animals were given intravenou...

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Detalhes bibliográficos
Main Authors: Bischoff, Angela, Czyborra, Peter, Meyer zu Heringdorf, Dagmar, Jakobs, Karl H, Michel, Martin C
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572274/
https://ncbi.nlm.nih.gov/pubmed/10952678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703516
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