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Impaired platelet responses to thrombin and collagen in AKT-1—deficient mice
We investigated the role of Akt-1, one of the major downstream effectors of phosphoinositide 3-kinase (PI3K), in platelet function using mice in which the gene for Akt-1 had been inactivated. Using ex vivo techniques, we showed that Akt-1–deficient mice exhibited impaired platelet aggregation and sp...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1569945/ https://ncbi.nlm.nih.gov/pubmed/15105289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2003-10-3428 |
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