The deficiency of Akt1 is sufficient to suppress tumor development in Pten(+/−) mice

The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN inactivation. It is not known, however, whether diminished Akt activity is sufficient to inhibit tumorigenesis initiated by Pten deficiency. Here we show...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chen, Mei-Ling, Xu, Pei-Zhang, Peng, Xiao, Chen, William S., Guzman, Grace, Yang, Ximing, Di Cristofano, Antonio, Pandolfi, Pier Paolo, Hay, Nissim
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2006
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482477/
https://ncbi.nlm.nih.gov/pubmed/16778075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1395006
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