The deficiency of Akt1 is sufficient to suppress tumor development in Pten(+/−) mice

The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN inactivation. It is not known, however, whether diminished Akt activity is sufficient to inhibit tumorigenesis initiated by Pten deficiency. Here we show...

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Autors principals: Chen, Mei-Ling, Xu, Pei-Zhang, Peng, Xiao, Chen, William S., Guzman, Grace, Yang, Ximing, Di Cristofano, Antonio, Pandolfi, Pier Paolo, Hay, Nissim
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2006
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482477/
https://ncbi.nlm.nih.gov/pubmed/16778075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1395006
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