The deficiency of Akt1 is sufficient to suppress tumor development in Pten(+/−) mice

The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN inactivation. It is not known, however, whether diminished Akt activity is sufficient to inhibit tumorigenesis initiated by Pten deficiency. Here we show...

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Bibliografiske detaljer
Main Authors: Chen, Mei-Ling, Xu, Pei-Zhang, Peng, Xiao, Chen, William S., Guzman, Grace, Yang, Ximing, Di Cristofano, Antonio, Pandolfi, Pier Paolo, Hay, Nissim
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2006
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482477/
https://ncbi.nlm.nih.gov/pubmed/16778075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1395006
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