The deficiency of Akt1 is sufficient to suppress tumor development in Pten(+/−) mice

The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN inactivation. It is not known, however, whether diminished Akt activity is sufficient to inhibit tumorigenesis initiated by Pten deficiency. Here we show...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Chen, Mei-Ling, Xu, Pei-Zhang, Peng, Xiao, Chen, William S., Guzman, Grace, Yang, Ximing, Di Cristofano, Antonio, Pandolfi, Pier Paolo, Hay, Nissim
פורמט: Artigo
שפה:Inglês
יצא לאור: Cold Spring Harbor Laboratory Press 2006
נושאים:
Research Communication
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482477/
https://ncbi.nlm.nih.gov/pubmed/16778075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1395006
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