Activation of Akt/Protein Kinase B Overcomes a G(2)/M Cell Cycle Checkpoint Induced by DNA Damage

Activation of Akt, or protein kinase B, is frequently observed in human cancers. Here we report that Akt activation via overexpression of a constitutively active form or via the loss of PTEN can overcome a G(2)/M cell cycle checkpoint that is induced by DNA damage. Activated Akt also alleviates the...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kandel, Eugene S., Skeen, Jennifer, Majewski, Nathan, Di Cristofano, Antonio, Pandolfi, Pier Paolo, Feliciano, Claudine S., Gartel, Andrei, Hay, Nissim
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2002
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC134727/
https://ncbi.nlm.nih.gov/pubmed/12391152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.22.7831-7841.2002
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