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Activation of Akt/Protein Kinase B Overcomes a G(2)/M Cell Cycle Checkpoint Induced by DNA Damage
Activation of Akt, or protein kinase B, is frequently observed in human cancers. Here we report that Akt activation via overexpression of a constitutively active form or via the loss of PTEN can overcome a G(2)/M cell cycle checkpoint that is induced by DNA damage. Activated Akt also alleviates the...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC134727/ https://ncbi.nlm.nih.gov/pubmed/12391152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.22.7831-7841.2002 |
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