Effects of a new C5a receptor antagonist on C5a- and endotoxin- induced neutropenia in the rat

A new C5a receptor antagonist, the cyclic peptide Phe-[Orn-Pro-D-cyclohexylalanine-Trp-Arg], (F-[OPdChaWR]), was tested for its ability to antagonize the neutropenic effects of both C5a and endotoxin in rats. Human recombinant C5a (2 μg kg(−1) i.v.) caused rapid neutropenia, characterized by an 83%...

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Hlavní autoři: Short, Anna, Wong, Allan K, Finch, Angela M, Haaima, Gerald, Shiels, Ian A, Fairlie, David P, Taylor, Stephen M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1999
Témata:
Special Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565845/
https://ncbi.nlm.nih.gov/pubmed/10188960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702338
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