Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist

1. Initiation of a peritoneal Arthus reaction by deposition of immune-complexes results in vascular leakage, polymorphonuclear leukocyte (PMN) infiltration, and tumour necrosis factor α (TNFα) and interleukin-6 (IL-6) production. We now demonstrate in rats that oral administration of the C5a recepto...

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Bibliographic Details
Main Authors: Strachan, Anna J, Shiels, Ian A, Reid, Robert C, Fairlie, David P, Taylor, Stephen M
Format: Artigo
Language:Inglês
Published: 2001
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572898/
https://ncbi.nlm.nih.gov/pubmed/11739255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704417
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