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Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist
1. Initiation of a peritoneal Arthus reaction by deposition of immune-complexes results in vascular leakage, polymorphonuclear leukocyte (PMN) infiltration, and tumour necrosis factor α (TNFα) and interleukin-6 (IL-6) production. We now demonstrate in rats that oral administration of the C5a recepto...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572898/ https://ncbi.nlm.nih.gov/pubmed/11739255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704417 |
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