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Effects of a new C5a receptor antagonist on C5a- and endotoxin- induced neutropenia in the rat
A new C5a receptor antagonist, the cyclic peptide Phe-[Orn-Pro-D-cyclohexylalanine-Trp-Arg], (F-[OPdChaWR]), was tested for its ability to antagonize the neutropenic effects of both C5a and endotoxin in rats. Human recombinant C5a (2 μg kg(−1) i.v.) caused rapid neutropenia, characterized by an 83%...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565845/ https://ncbi.nlm.nih.gov/pubmed/10188960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702338 |
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