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The effect of glibenclamide on the production of interstitial adenosine by inhibiting ecto-5′-nucleotidase in rat hearts

1. Adenosine exerts cardioprotective effects on the ischaemic myocardium. The production of adenosine in the ischaemic myocardium is attributed primarily to the enzymatic dephosphorylation of adenosine 5′-monophosphate (AMP) by 5′-nucleotidase. We determined the activity of 5′-nucleotidase in rat he...

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Main Authors: Sato, Toshiaki, Obata, Toshio, Yamanaka, Yasumitsu, Arita, Makoto
格式: Artigo
語言:Inglês
出版: 1997
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564982/
https://ncbi.nlm.nih.gov/pubmed/9375955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701424
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