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Inhibition by ATP of Hippocampal Synaptic Transmission Requires Localized Extracellular Catabolism by Ecto-Nucleotidases into Adenosine and Channeling to Adenosine A(1) Receptors

ATP analogs substituted in the γ-phosphorus (ATPγS, β,γ-imido-ATP, and β,γ-methylene-ATP) were used to probe the involvement of P(2) receptors in the modulation of synaptic transmission in the hippocampus, because their extracellular catabolism was virtually not detected in CA1 slices. ATP and γ-sub...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Cunha, Rodrigo A., Sebastião, Ana M., Ribeiro, J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792930/
https://ncbi.nlm.nih.gov/pubmed/9482785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-06-01987.1998
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