Importance of Neuraminidase Active-Site Residues to the Neuraminidase Inhibitor Resistance of Influenza Viruses

Neuraminidase inhibitors (NAIs) are antivirals designed to target conserved residues at the neuraminidase (NA) enzyme active site in influenza A and B viruses. The conserved residues that interact with NAIs are under selective pressure, but only a few have been linked to resistance. In the A/Wuhan/3...

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Autors principals: Yen, Hui-Ling, Hoffmann, Erich, Taylor, Garry, Scholtissek, Christoph, Monto, Arnold S., Webster, Robert G., Govorkova, Elena A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563878/
https://ncbi.nlm.nih.gov/pubmed/16912325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00477-06
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