Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
The DNA damage-dependent poly(ADP-ribose) polymerases, PARP-1 and PARP-2, homo- and heterodimerize and are both involved in the base excision repair (BER) pathway. Here, we report that mice carrying a targeted disruption of the PARP-2 gene are sensitive to ionizing radiation. Following alkylating ag...
Guardat en:
| Publicat a: | EMBO J |
|---|---|
| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156078/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12727891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg206 |
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