Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

The DNA damage-dependent poly(ADP-ribose) polymerases, PARP-1 and PARP-2, homo- and heterodimerize and are both involved in the base excision repair (BER) pathway. Here, we report that mice carrying a targeted disruption of the PARP-2 gene are sensitive to ionizing radiation. Following alkylating ag...

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Main Authors: Ménissier de Murcia, Josiane, Ricoul, Michelle, Tartier, Laurence, Niedergang, Claude, Huber, Aline, Dantzer, Françoise, Schreiber, Valérie, Amé, Jean-Christophe, Dierich, Andrée, LeMeur, Marianne, Sabatier, Laure, Chambon, Pierre, de Murcia, Gilbert
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC156078/
https://ncbi.nlm.nih.gov/pubmed/12727891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg206
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