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Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
The DNA damage-dependent poly(ADP-ribose) polymerases, PARP-1 and PARP-2, homo- and heterodimerize and are both involved in the base excision repair (BER) pathway. Here, we report that mice carrying a targeted disruption of the PARP-2 gene are sensitive to ionizing radiation. Following alkylating ag...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2003
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC156078/ https://ncbi.nlm.nih.gov/pubmed/12727891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg206 |
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