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Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide
Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that specifically silence the mutant disease allele, whi...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2006
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1560399/ https://ncbi.nlm.nih.gov/pubmed/16965178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020140 |
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