Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide

Small interfering RNAs (siRNAs), the guides that direct RNA interference (RNAi), provide a powerful tool to reduce the expression of a single gene in human cells. Ideally, dominant, gain-of-function human diseases could be treated using siRNAs that specifically silence the mutant disease allele, whi...

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Bibliographische Detailangaben
Hauptverfasser: Schwarz, Dianne S, Ding, Hongliu, Kennington, Lori, Moore, Jessica T, Schelter, Janell, Burchard, Julja, Linsley, Peter S, Aronin, Neil, Xu, Zuoshang, Zamore, Phillip D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560399/
https://ncbi.nlm.nih.gov/pubmed/16965178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020140
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