CD40 Contributes to Lethality in Acute Sepsis: In Vivo Role for CD40 in Innate Immunity

Sepsis induces an early inflammatory cascade initiated by the innate immune response. This often results in the development of multisystem organ failure. We examined the role of CD40, a costimulatory molecule that is integral in adaptive immunity, by using a murine model of polymicrobial sepsis. CD4...

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Bibliografische Detailangaben

Veröffentlicht in:	Infect Immun
Hauptverfasser:	Gold, Jeffrey A., Parsey, Merdad, Hoshino, Yoshihiko, Hoshino, Satomi, Nolan, Anna, Yee, Herman, Tse, Doris B., Weiden, Michael D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Host Response and Inflammation
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155725/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12761137/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.6.3521-3528.2003
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