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Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice

Centromere protein A (Cenpa for mouse, CENP-A for other species) is a histone H3-like protein that is thought to be involved in the nucleosomal packaging of centromeric DNA. Using gene targeting, we have disrupted the mouse Cenpa gene and demonstrated that the gene is essential. Heterozygous mice ar...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Howman, Emily V., Fowler, Kerry J., Newson, Ainsley J., Redward, Saara, MacDonald, Andrew C., Kalitsis, Paul, Choo, K. H. Andy
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15551/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10655499/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.3.1148
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