Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons

Mitochondria are present as tubular organelles in neuronal projections. Here, we report that mitochondria undergo profound fission in response to nitric oxide (NO) in cortical neurons of primary cultures. Mitochondrial fission by NO occurs long before neurite injury and neuronal cell death. Furtherm...

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Autors principals: Barsoum, Mark J, Yuan, Hua, Gerencser, Akos A, Liot, Géraldine, Kushnareva, Yulia, Gräber, Simone, Kovacs, Imre, Lee, Wilson D, Waggoner, Jenna, Cui, Jiankun, White, Andrew D, Bossy, Blaise, Martinou, Jean-Claude, Youle, Richard J, Lipton, Stuart A, Ellisman, Mark H, Perkins, Guy A, Bossy-Wetzel, Ella
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1553198/
https://ncbi.nlm.nih.gov/pubmed/16874299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601253
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