MUTANT HUNTINGTIN BINDS THE MITOCHONDRIAL FISSION GTPASE DRP1 AND INCREASES ITS ENZYMATIC ACTIVTY

Huntington disease (HD) is an inherited and incurable neurodegenerative disorder caused by an abnormal polyglutamine (polyQ) expansion in huntingtin (HTT). PolyQ length determines disease onset and severity with a longer expansion causing earlier onset. The mechanisms of mutant HTT-mediated neurotox...

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Main Authors: Song, Wenjun, Chen, Jin, Petrilli, Alejandra, Liot, Geraldine, Klinglmayr, Eva, Zhou, Yue, Poquiz, Patrick, Tjong, Jonathan, Pouladi, Mahmoud A., Hayden, Michael R., Masliah, Eliezer, Ellisman, Mark, Rouiller, Isabelle, Schwarzenbacher, Robert, Bossy, Blaise, Perkins, Guy, Bossy-Wetzel, Ella
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051025/
https://ncbi.nlm.nih.gov/pubmed/21336284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2313
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