Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity

Optic atrophy 1 (OPA1) mutations cause dominant optic atrophy (DOA) with retinal ganglion cell (RGC) and optic nerve degeneration. The mechanism for the selective degeneration of RGCs in DOA remains elusive. To address the mechanism, we reduced OPA1 protein expression in cell lines and RGCs by RNA i...

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Autors principals: Kushnareva, Y E, Gerencser, A A, Bossy, B, Ju, W-K, White, A D, Waggoner, J, Ellisman, M H, Perkins, G, Bossy-Wetzel, E
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554330/
https://ncbi.nlm.nih.gov/pubmed/23138851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.128
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