Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity

Optic atrophy 1 (OPA1) mutations cause dominant optic atrophy (DOA) with retinal ganglion cell (RGC) and optic nerve degeneration. The mechanism for the selective degeneration of RGCs in DOA remains elusive. To address the mechanism, we reduced OPA1 protein expression in cell lines and RGCs by RNA i...

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Detalhes bibliográficos
Main Authors: Kushnareva, Y E, Gerencser, A A, Bossy, B, Ju, W-K, White, A D, Waggoner, J, Ellisman, M H, Perkins, G, Bossy-Wetzel, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554330/
https://ncbi.nlm.nih.gov/pubmed/23138851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.128
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