Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis

A direct link between Ca(2+) and lipid homeostasis has not been definitively demonstrated. In this study, we show that manipulation of ER Ca(2+) causes the re-distribution of a portion of the intracellular unesterified cholesterol to a pool that is not available to the SCAP-SREBP complex. The SREBP...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Wang, Wen-An, Liu, Wen-Xin, Durnaoglu, Serpen, Lee, Sun-Kyung, Lian, Jihong, Lehner, Richard, Ahnn, Joohong, Agellon, Luis B., Michalak, Marek
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517566/
https://ncbi.nlm.nih.gov/pubmed/28725049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05734-x
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