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Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis
A direct link between Ca(2+) and lipid homeostasis has not been definitively demonstrated. In this study, we show that manipulation of ER Ca(2+) causes the re-distribution of a portion of the intracellular unesterified cholesterol to a pool that is not available to the SCAP-SREBP complex. The SREBP...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5517566/ https://ncbi.nlm.nih.gov/pubmed/28725049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05734-x |
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