DNA-PK autophosphorylation facilitates Artemis endonuclease activity

The Artemis nuclease is defective in radiosensitive severe combined immunodeficiency patients and is required for the repair of a subset of ionising radiation induced DNA double-strand breaks (DSBs) in an ATM and DNA-PK dependent process. Here, we show that Artemis phosphorylation by ATM and DNA-PK...

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Detalhes bibliográficos
Main Authors: Goodarzi, Aaron A, Yu, Yaping, Riballo, Enriqueta, Douglas, Pauline, Walker, Sarah A, Ye, Ruiqiong, Härer, Christine, Marchetti, Caterina, Morrice, Nick, Jeggo, Penny A, Lees-Miller, Susan P
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1553186/
https://ncbi.nlm.nih.gov/pubmed/16874298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601255
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